Synthesis and anti-picornavirus activity of homo-isoflavonoids
作者： N Desideri , S Olivieri , Ml Stein , R Sgro , N Orsi
DOI: 10.1177/095632029700800609
关键词: In vitro 、 Picornavirus 、 Rhinovirus 、 Biochemistry 、 Substituent 、 Biology 、 Virus 、 Poliovirus 、 HeLa 、 Flavonoid 、 Stereochemistry
摘要: Substituted homo-isoflavonoids were synthesized in order to study their vitro anti-picornavirus activity. The maximum non-toxic concentration of the compounds for susceptible cells (HeLa) was determined, and ability non-cytotoxic concentrations interfere with plaque formation by human rhinovirus (HRV) 1B 14 poliovirus (PV) 2 examined. All tested weakly effective against PV-2, while they exhibited a variable degree activity HRV-1B -14 infection. Serotype much more sensitive than action compounds, presence one or chlorine atoms increased antiviral effect all tested, confirming positive influence this substituent on
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