Evolution of New Variants/Mutants of JE Virus, Its Effect on Neurovirulence, Antigenicity, Host Immune Responses and Disease Transmission in Endemic Areas
作者： Ravi Kant Upadhyay
DOI: 10.1155/2014/516904
关键词: Genetic recombination 、 Virology 、 Antigenicity 、 Point mutation 、 Gene 、 Viral replication 、 Virus 、 Genetic variation 、 Genetics 、 Biology 、 Genotype
摘要: This paper highlights various reasons of evolution new mutants/variants JE virus and its effects on neurovirulence, antigenicity, host immune responses, disease transmission in endemic areas. Virus is reorganizing genome by making sequence alterations, single site mutations, cluster specific reversions, amino acid substitutions neutralizing antigenic sites mainly N′ glycosylation epitopic regions S E proteins. regularly changing gene order, density substitution point mutations important structural genes which make envelope Further, acquiring genetic variations adaptabilities through recombination wild strains with vaccine assimilating lethal that lead to emergence molecular variants/mutants. These newly emerged genotypes have attained the ability escape defense show wider resistance against vaccines therapeutic agents. Thus did significant elevation level antigenicity pathogenesis. It causing very high mortalities infant groups imposing lifelong irreversible disorders survivors showing a regular trend reemergence The present review article emphasizes methods suppress replication, reversion attenuation an utmost need more potential cross reactive heterologous control occurring
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