Incidence of contrast-induced acute kidney injury in a large cohort of all-comers undergoing percutaneous coronary intervention: Comparison of five contrast media.

摘要: Abstract Background There is controversy as to whether iso-osmolar contrast media (IOCM) are associated with lower risk of contrast-induced acute kidney injury (CI-AKI), compared low-osmolar (LOCM). We aimed evaluate if a differential CI-AKI exists after percutaneous coronary intervention (PCI) according different (CM) types. Methods performed single-center retrospective study in cohort all-comers undergoing PCI between January 2012 and December 2016. was defined an increase serum creatinine ≥0.3 mg/dl or ≥50% within 72 h from PCI. IOCM were represented by iodixanol, whereas four LOCM utilized (ioversol, iopromide, iomeprol, iobitridol). Multiple-treatment inverse probability treatment weighting (IPTW)-adjusted logistic regression analysis identify CM type independent predictor CI-AKI. Results included 2648 subjects n = 272; n = 818; n = 611; iobitridol, n = 460; n = 487). occurred 300 patients (11.7%) overall, no differences across groups (ioversol 13.0%, iopromide 11.5%, iomeprol 10.2%, iobitridol 13.9%, iodixanol 11.3%; p = 0.42). requiring dialysis observed 8 (0.3%) overall (p = 0.50). On IPTW-adjusted analysis, none the significantly iodixanol: ioversol OR 0.986 (95% confidence interval [CI] 0.611–1.591), 0.870 CI 0.606–1.250), 0.904 0.619–1.319), 1.258 0.850–1.861). Conclusions In large PCI, there adjusted 4 LOCM, iodixanol.