USE OF PYRIDOXINE HYDROCHLORIDE TO PREVENT ISONIAZID TOXICITY

摘要: There have been several recent reports 1 regarding the ability of pyridoxine hydrochloride and its derivatives, pyridoxal pyridoxamine, to prevent or delay appearance peripheral neuritis due isoniazid administration. This finding was followed by suggestion that it is now possible use much larger doses (6 20 mg. per kilogram body weight) than used routinely heretofore (3 5 weight). Subsequently, Pope 2 has shown pyridoxamine can interfere with tuberculostatic action in vitro, McCune 3 an vivo interference pyridoxine. The present study undertaken confirm deny earlier toxic effects resulting from large could be prevented concomitant administration Methods Results Forty-eight patients were given