Insulin resistance in relatives of NIDDM patients: the role of physical fitness and muscle metabolism.

摘要: First degree relatives of patients with non-insulin-dependent diabetes mellitus (NIDDM) are often reported to be insulin resistant. To examine the possible role reduced physical fitness in this condition 21 first NIDDM and 22 control subjects without any history were examined employing a 150-min hyper-insulinaemic (0.6 mU kg−1 min−1) euglycaemic clamp combined isotope dilution technique (3-3H-glucose, Hot GINF), forearm indirect calorimetry. During hyperinsulinaemia glucose disposal (Rd) extraction significantly diminished (p < 0.01 p 0.05), but oxidation suppressive effect on hepatic production normal. Arteriovenous differences across gluconeogenic precursors lactate, alanine glycerol as well increments blood flow during similar two groups. Maximal oxygen uptake (VO2 max) was lower than (36.8 ± 1.9 vs 42.1 2.0 ml min−1; = 0.03). There highly significant correlation between Rd VO2 max both (r 0.68 0.66, respectively; 0.001). Comparison linear regression analyses insulin-stimulated groups showed no slopes (0.10 0.03 0.09 0.02) or intercepts. In stepwise multiple insulinstimulated dependent variable determined level 0.01), whereas anthropometric data did not. conclusion, resistance healthy is associated work capacity. Whether, finding ascribable environmental genetic factors (e.g. muscle fibre types, capillary density etc) remains determined.