Fatty liver indices in the multiethnic United States National Health and Nutrition Examination Survey.

摘要: SummaryBackground Validated non-invasive measures of fatty liver are needed that can be applied across populations and over time. A index (FLI) including body mass index, waist circumference, triglycerides gamma glutamyltransferase (GGT) activity was developed in an Italian municipality, but has not been validated widely or examined a multiethnic population. Aims We evaluated this FLI the U.S. National Health Nutrition Examination Survey (NHANES) also to explore whether improved for population (US FLI) could derived. The US would then used examine time trends prevalence. Methods We studied 5869 fasted, viral hepatitis negative adult participants with abdominal ultrasound data on 1988–1994 NHANES. Time trend analyses included 21 712 NHANES 1999–2012 participants. Results The prevalence 20%. For FLI, area under receiver operating characteristic curve [AUC; 95% confidence interval (CI)] 0.78 (0.74–0.81). age, race-ethnicity, GGT activity, fasting insulin glucose had AUC (95% CI) 0.80 (0.77–0.83). Defining as ≥ 30, increased from 18% 1988–1991 29% 1999–2000 31% 2011–2012. Conclusions For predicting liver, modest improvement population. Using measure, substantially two decades.