Oral delivery of macromolecules: rationale underpinning Gastrointestinal Permeation Enhancement Technology (GIPET®)
作者： Edwin G Walsh , Bozena E Adamczyk , Kishore B Chalasani , Sam Maher , Edel B O’Toole
DOI: 10.4155/TDE.11.132
关键词: Medicine 、 Permeation 、 Paracellular transport 、 Delivery system 、 Transcellular 、 Pharmacology 、 Oral retinoid 、 Tight junction
摘要: Oral delivery of macromolecular drugs, particularly peptides and proteins, is the focus many academic industrial laboratories. Armed with an increased understanding structure regulation intestinal epithelial junctional complexes paracellular barrier, development permeation enhancement technology initially focused on specific reversible opening tight junctions in order to enable oral delivery. Despite intense research, none these junction-opening technologies has yet been approved drug product, likely because poor efficacy. Less enhancer a long history safe use man have additional surfactant-like effects transcellular pathway that lead improved These are be first market for selected poorly permeable peptides. This review presents summary some approaches taken explores detail system developed by Merrion Pharmaceuticals, Gastrointestinal Permeation Enhancement Technology (GIPET).
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