Thermosensitive dendrimer formulation for drug delivery at physiologically relevant temperatures
作者： Annie Castonguay , Eleanor Wilson , Noura Al-Hajaj , Laurène Petitjean , Julie Paoletti
DOI: 10.1039/C1CC15354D
关键词: Lipoic acid 、 Dendrimer 、 Biophysics 、 Drug delivery 、 Conjugated system 、 Organic chemistry 、 Chemistry
摘要: A simple and versatile dendrimer based platform to deliver therapeutic agents at temperatures within the physiological range, is reported. Lipoic acid conjugated periphery of thermosensitive formulations undergoes slow sustained release 37–42 °C, rescues cells from oxidative stress a pro-inflammatory endotoxic agent.
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