Microchip-based electrochemical detection for monitoring cellular systems

作者: Alicia S. Johnson , Asmira Selimovic , R. Scott Martin

DOI: 10.1007/S00216-012-6682-3

关键词: NanotechnologyMicrochip Analytical ProceduresExtramuralComputer scienceElectrochemical detectionSingle-cell analysis

摘要: The use of microchip devices to study cellular systems is a rapidly growing research area. There are numerous advantages using on-chip integrated electrodes monitor various processes. purpose this review give examples advancements in microchip-based analysis, specifically where electrochemistry used for the detection scheme. These include single-cell quantal exocytosis, electrochemical analysis intracellular contents, ability integrate cell culture/immobilization with electrochemistry, and ensure confluency longer-term culture experiments. A perspective on future trends area also given.

参考文章(66)
Kae Sato, Kazuma Mawatari, Takehiko Kitamori, Microchip-based cell analysis and clinical diagnosis system. Lab on a Chip. ,vol. 8, pp. 1992- 1998 ,(2008) , 10.1039/B814098G
Gregor Ocvirk, Thompson Tang, D. Jed Harrison, Optimization of confocal epifluorescence microscopy for microchip-based miniaturized total analysis systems Analyst. ,vol. 123, pp. 1429- 1434 ,(1998) , 10.1039/A800153G
Michelle L. Kovarik, Philip C. Gach, Douglas M. Ornoff, Yuli Wang, Joseph Balowski, Lila Farrag, Nancy L. Allbritton, Micro total analysis systems for cell biology and biochemical assays. Analytical Chemistry. ,vol. 84, pp. 516- 540 ,(2012) , 10.1021/AC202611X
Syed Barizuddin, Xin Liu, Joseph C Mathai, Maruf Hossain, Kevin, D Gillis, Shubhra Gangopadhyay, Automated Targeting of Cells to Electrochemical Electrodes Using a Surface Chemistry Approach for the Measurement of Quantal Exocytosis ACS Chemical Neuroscience. ,vol. 1, pp. 590- 597 ,(2010) , 10.1021/CN1000183
Keil J. Regehr, Maribella Domenech, Justin T. Koepsel, Kristopher C. Carver, Stephanie J. Ellison-Zelski, William L. Murphy, Linda A. Schuler, Elaine T. Alarid, David J. Beebe, Biological implications of polydimethylsiloxane-based microfluidic cell culture. Lab on a Chip. ,vol. 9, pp. 2132- 2139 ,(2009) , 10.1039/B903043C
Paul M. van Midwoud, Arnout Janse, Marjolijn T. Merema, Geny M. M. Groothuis, Elisabeth Verpoorte, Comparison of Biocompatibility and Adsorption Properties of Different Plastics for Advanced Microfluidic Cell and Tissue Culture Models Analytical Chemistry. ,vol. 84, pp. 3938- 3944 ,(2012) , 10.1021/AC300771Z
A. Manz, N. Graber, H.M. Widmer, Miniaturized total chemical analysis systems: A novel concept for chemical sensing Sensors and Actuators B: Chemical. ,vol. 1, pp. 244- 248 ,(1990) , 10.1016/0925-4005(90)80209-I
Xin Liu, Syed Barizuddin, Wonchul Shin, Cherian J. Mathai, Shubhra Gangopadhyay, Kevin D. Gillis, Microwell device for targeting single cells to electrochemical microelectrodes for high-throughput amperometric detection of quantal exocytosis. Analytical Chemistry. ,vol. 83, pp. 2445- 2451 ,(2011) , 10.1021/AC1033616
Dongeun Huh, Geraldine A. Hamilton, Donald E. Ingber, From 3D cell culture to organs-on-chips. Trends in Cell Biology. ,vol. 21, pp. 745- 754 ,(2011) , 10.1016/J.TCB.2011.09.005