The first eukaryotic kinome tree illuminates the dynamic history of present-day kinases
作者： Leny M. van Wijk , Berend Snel
DOI: 10.1101/2020.01.27.920793
关键词: Computational biology 、 Phylogenetic tree 、 Evolutionary dynamics 、 Eukaryotic cell 、 Kinome 、 Biology 、 Kinase 、 Tree (data structure)
摘要: Eukaryotic Protein Kinases (ePKs) are essential for eukaryotic cell signalling. Several phylogenetic trees of the ePK repertoire single eukaryotes have been published, including human kinome tree. However, a eukaryote-wide tree was missing due to large number kinases in eukaryotes. Using pipeline that overcomes this problem, we present here first The reveals Last Common Ancestor (LECA) possessed at least 92 ePKs, much more than previously thought. retention these LECA ePKs present-day species is highly variable. Fourteen with unresolved placement were found originate from three known superfamilies. Further analysis superfamilies shows they exhibit markedly diverse evolutionary dynamics between and thus unveils history but also enables transfer functional information related kinases.
sci-hub.st 参考文章(61)
Yinhuai Chen, Yolanda Sanchez, Chk1 in the DNA damage response: conserved roles from yeasts to mammals. DNA Repair. ,vol. 3, pp. 1025- 1032 ,(2004) , 10.1016/J.DNAREP.2004.03.003
Monika Zulawski, Gunnar Schulze, Rostyslav Braginets, Stefanie Hartmann, Waltraud X Schulze, The Arabidopsis Kinome: phylogeny and evolutionary insights into functional diversification. BMC Genomics. ,vol. 15, pp. 548- 548 ,(2014) , 10.1186/1471-2164-15-548
Andreas Spitzmüller, Jordi Mestres, Prediction of the P. falciparum Target Space Relevant to Malaria Drug Discovery PLoS Computational Biology. ,vol. 9, pp. e1003257- ,(2013) , 10.1371/JOURNAL.PCBI.1003257
Anna Kulik, Izabela Wawer, Ewa Krzywińska, Maria Bucholc, Grażyna Dobrowolska, SnRK2 protein kinases--key regulators of plant response to abiotic stresses. Omics A Journal of Integrative Biology. ,vol. 15, pp. 859- 872 ,(2011) , 10.1089/OMI.2011.0091
Brande B. H. Wulff, Matthew J. Moscou, Strategies for transferring resistance into wheat: from wide crosses to GM cassettes Frontiers in Plant Science. ,vol. 5, pp. 692- 692 ,(2014) , 10.3389/FPLS.2014.00692
Gerard Manning, David B Whyte, Ricardo Martinez, Tony Hunter, Sucha Sudarsanam, The Protein Kinase Complement of the Human Genome Science. ,vol. 298, pp. 1912- 1934 ,(2002) , 10.1126/SCIENCE.1075762
Sergi Aranda, Ariadna Laguna, Susana de la Luna, DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles The FASEB Journal. ,vol. 25, pp. 449- 462 ,(2011) , 10.1096/FJ.10-165837
Hideki Innan, Fyodor Kondrashov, The evolution of gene duplications: classifying and distinguishing between models Nature Reviews Genetics. ,vol. 11, pp. 97- 108 ,(2010) , 10.1038/NRG2689
Natarajan Kannan, Susan S Taylor, Yufeng Zhai, J. Craig Venter, Gerard Manning, Structural and functional diversity of the microbial kinome. PLOS Biology. ,vol. 5, ,(2007) , 10.1371/JOURNAL.PBIO.0050017
Felix Bemm, Roland Schwarz, Frank Förster, Jörg Schultz, A kinome of 2600 in the ciliate Paramecium tetraurelia. FEBS Letters. ,vol. 583, pp. 3589- 3592 ,(2009) , 10.1016/J.FEBSLET.2009.10.029