Subchronic toxicity of rebaudioside A.

摘要: Abstract The safety of the stevia-derived sweetener, rebaudioside A (CAS No. 58543-16-1), was evaluated in two oral toxicity studies. In a 4-week study, Wistar rats were administered at dietary concentrations 0, 25,000, 50,000, 75,000 and 100,000 ppm. NOAEL, including an evaluation testes histopathology, determined to be 100,000 ppm. 13-week 12,500, 25,000 50,000 ppm. Reductions body weight gain attributable initial taste aversion lower caloric density diet observed high-dose male females groups. Inconsistent reductions serum bile acids cholesterol attributed physiological changes acid metabolism due excretion high levels via liver. All other hepatic function test results liver histopathology within normal limits. Significant clinical pathology results, organ weights functional observational battery not observed. Macroscopic microscopic examinations all organs, kidneys, unremarkable with respect treatment-related findings. NOAEL study considered 50,000 ppm or approximately 4161 4645 mg/kg weight/day female rats, respectively.