ELectrokinetic traps for integrated biological sample analysis

摘要: A new device integrating diverse electrokinetic steps is presented to extract and enrich analytes directly from blood followed by electrophoretic separation. Two sequentially coupled nanojunctions with different pore size formed a trap selective ion transport properties. The balance between depletion forces near the and/or apparent electromigration can be tuned for analysis of proteins, DNA, or pharmaceuticals. Here, we demonstrate ampicillin within 5 min. obtained linear range 2.5-20 μg/mL covers therapeutically relevant concentration treating sepsis.