Physiology of erectile function.

摘要: ABSTRACT Introduction There are numerous investigations concerning the balance and interactions between relaxant contractile factors regulating penile smooth muscle (arterial trabecular) tone, determinant of flaccidity or erection. Enhanced knowledge erectile physiology may improve management men with dysfunction. Aim To provide state‐of‐the‐art on function. Methods An international consultation in collaboration major urology sexual medicine associations assembled over 200 multidisciplinary experts from 60 countries into 17 committees. Committee members established specific objectives scopes for various male female topics. The recommendations respective topic represent opinion five continents developed a process two‐year period. Concerning function pathophysiology dysfunction committee, there were seven countries. Main Outcome Measure Expert was based grading evidence‐based medical literature, widespread internal committee discussion, public presentation, debate. Results Key roles mechanism determining tone played by rise intracellular concentration free calcium sensitivity machinery to calcium, endothelial health, endothelium‐derived nitric oxide, hyperpolarizing factor (EDHF), neuronal cyclic guanosine monophosphate‐dependent protein kinase phosphodiesterase type 5. Conclusions A number new mechanisms have been identified local regulation contractility therefore Molecules participating these pathways can be considered targets development treatments treat