Noninfectious and Nonmalignant Complications of Anti-TNF Therapy

摘要: Anti-TNF therapies are commonly used in the treatment of moderate to severe inflammatory bowel disease. The noninfectious and nonmalignant complications anti-TNF therapy include infusion or injection site reactions, psoriasiform eczematous eruptions, lupus-like reaction, hepatotoxicity, demyelination, heart failure. Infusion/injection dermatologic reactions often can be managed with supportive care without discontinuation anti-TNF. Early recognition management these is important initiate if indicated, minimize symptoms, transition other necessary. This chapter focuses on clinical presentation, pathophysiology, diagnostic evaluation, therapy.