Hypermethylation of gene body CpG islands predicts high dosage of functional oncogenes in liver cancer
作者： Maria Arechederra , Fabrice Daian , Annie Yim , Sehrish K. Bazai , Sylvie Richelme
DOI: 10.1038/S41467-018-05550-5
关键词: DNA methylation 、 Biology 、 Regulation of gene expression 、 Cancer 、 CpG site 、 Oncogene 、 Epigenetics 、 Body region 、 Cancer research 、 Carcinogenesis
摘要: … hepatocellular carcinoma (HCC) mouse model (Alb-R26 Met ) to explore the impact of DNA … histone mutations or alterations in genes regulating DNA methylation–histone modifications …
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Augusto Villanueva, Anna Portela, Sergi Sayols, Carlo Battiston, Yujin Hoshida, Jesús Méndez-González, Sandrine Imbeaud, Eric Letouzé, Virginia Hernandez-Gea, Helena Cornella, Roser Pinyol, Manel Solé, Josep Fuster, Jessica Zucman-Rossi, Vincenzo Mazzaferro, Manel Esteller, Josep M. Llovet, , DNA methylation-based prognosis and epidrivers in hepatocellular carcinoma Hepatology. ,vol. 61, pp. 1945- 1956 ,(2015) , 10.1002/HEP.27732
Fan Yannan, Richelme Sylvie, Avazeri Emilie, Audebert Stéphane, Helmbacher Françoise, Dono Rosanna, Flavio, Maina, Tissue-Specific Gain of RTK Signalling Uncovers Selective Cell Vulnerability during Embryogenesis PLOS Genetics. ,vol. 11, pp. e1005533- ,(2015) , 10.1371/JOURNAL.PGEN.1005533
François Karch, In vivo studies of the Drosophila insulator factor CTCF reach a Catch 22 BMC Biology. ,vol. 13, pp. 71- 71 ,(2015) , 10.1186/S12915-015-0182-9
Behnam Nabet, Pilib Ó Broin, Jaime M. Reyes, Kevin Shieh, Charles Y. Lin, Christine M. Will, Relja Popovic, Teresa Ezponda, James E. Bradner, Aaron A. Golden, Jonathan D. Licht, Deregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape Cell Reports. ,vol. 12, pp. 1300- 1313 ,(2015) , 10.1016/J.CELREP.2015.06.078
Cathy L. Barr, Frank B. Furnari, Timothy F. Cloughesy, William H. Yong, Timothy C. Gahman, Andrew K. Shiau, Webster K. Cavenee, Bing Ren, Paul S. Mischel, Feng Liu, Gary C. Hon, Genaro R. Villa, Kristen M. Turner, Shiro Ikegami, Huijun Yang, Zhen Ye, Bin Li, Samantha Kuan, Ah Young Lee, Ciro Zanca, Bowen Wei, Greg Lucey, David Jenkins, Wei Zhang, EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling Molecular Cell. ,vol. 60, pp. 307- 318 ,(2015) , 10.1016/J.MOLCEL.2015.09.002
Flavio Maina, Strategies to overcome drug resistance of receptor tyrosine kinaseaddicted cancer cells. Current Medicinal Chemistry. ,vol. 21, pp. 1607- 1617 ,(2014) , 10.2174/09298673113209990222
Nilofer Azad, Cynthia A. Zahnow, Charles M. Rudin, Stephen B. Baylin, The future of epigenetic therapy in solid tumours--lessons from the past. Nature Reviews Clinical Oncology. ,vol. 10, pp. 256- 266 ,(2013) , 10.1038/NRCLINONC.2013.42
Maria A. Hahn, Xiwei Wu, Arthur X. Li, Torsten Hahn, Gerd P. Pfeifer, Relationship between Gene Body DNA Methylation and Intragenic H3K9me3 and H3K36me3 Chromatin Marks PLoS ONE. ,vol. 6, pp. e18844- ,(2011) , 10.1371/JOURNAL.PONE.0018844
Madeleine P Ball, Jin Billy Li, Yuan Gao, Je-Hyuk Lee, Emily M LeProust, In-Hyun Park, Bin Xie, George Q Daley, George M Church, Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells. Nature Biotechnology. ,vol. 27, pp. 361- 368 ,(2009) , 10.1038/NBT.1533
A Furlan, V Stagni, A Hussain, S Richelme, F Conti, A Prodosmo, A Destro, M Roncalli, D Barilà, F Maina, Abl interconnects oncogenic Met and p53 core pathways in cancer cells Cell Death & Differentiation. ,vol. 18, pp. 1608- 1616 ,(2011) , 10.1038/CDD.2011.23