Applications of transcriptional profiling in antibiotics discovery and development.
作者： Hans Peter Fischer , Christoph Freiberg
DOI: 10.1007/978-3-7643-7567-6_2
关键词: Safety studies 、 DNA microarray 、 Antibiotic Agents 、 Toxicogenomics 、 Microarray 、 Gene chip analysis 、 Computer science 、 Computational biology 、 Antibiotics 、 Profiling (information science)
摘要: This chapter will review specific applications of microarray technology and related data analysis strategies in antibacterial research development. We present examples spanning the entire antibiotics development pipeline, from target discovery, assay development, pharmacological evaluation, to compound safety studies. emphasizes utility microarrays for a systematic evaluation novel chemistry as antibiotic agents. Transcriptional profiling has revolutionized process elucidation potential offer substantial guidance identification new targets. Microarrays continue be workhorse anti-infectives discovery programs ranging efficacy assessments (‘forward pharmacology’) drug evaluations (‘toxicogenomics’).
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