Structure of the c-Ki-ras gene in a rat fibrosarcoma induced by 1,8-dinitropyrene.

作者： T Tahira , K Hayashi , M Ochiai , N Tsuchida , M Nagao

关键词: Transversion 、 Peptide sequence 、 Biochemistry 、 Molecular biology 、 Exon 、 Biology 、 Nucleic acid sequence 、 Cysteine 、 Glycine 、 Fibrosarcoma 、 Restriction enzyme

摘要: Restriction enzyme maps were made of the region around exons 1 and 2 activated c-Ki-ras a fibrosarcoma (1,8-DNP2) induced in rat by 1,8-dinitropyrene. Nucleotide sequence analysis revealed that shows G----T transversion codon 12 consequently encodes cysteine instead glycine normal c-Ki-ras.