Updates in the Management of Cephalosporin-Resistant Gram-Negative Bacteria

摘要: Resistance to cephalosporins is now common among Gram-negative bacterial infections, including those caused by the Enterobacteriaceae and Pseudomonas aeruginosa, posing a major threat public health. As resistance traditional drugs of choice for these carbapenems, has also become increasingly common, interest in cefepime piperacillin-tazobactam as carbapenem-sparing alternatives increased. Additionally, availability novel β-lactam-β-lactamase inhibitor combinations ceftolozane-tazobactam ceftazidime-avibactam added antimicrobial armamentarium available treat multidrug-resistant infections. Here, we review recent literature on use highlight potential utility antimicrobials.