White Matter Damage Relates to Oxygen Saturation in Children With Sickle Cell Anemia Without Silent Cerebral Infarcts

摘要: Background and Purpose—Sickle cell anemia is associated with compromised oxygen-carrying capability of hemoglobin a high incidence overt silent stroke. However, in children no evidence cerebral infarction, there are changes brain morphometry relative to healthy controls, which may be related chronic oxygen desaturation. Methods—A whole-brain tract-based spatial statistics analysis was carried out 25 sickle abnormality on T2-weighted magnetic resonance imaging (13 male, age range: 8–18 years) 14 age- race-matched controls (7 10–19 determine the extent white matter injury. The hypotheses that damage daytime peripheral saturation steady-state were tested. Results—Fractional anisotropy found significantly lower patients subcortical (corticospinal tract cerebellum), whereas mean diffusivity radial dif...