Synchronously counterpulsating extracorporeal life support enhances myocardial working conditions regardless of systemic perfusion pressure

摘要: Objective: A new pulsatile extracorporeal life support (pECLS) system has entered the market. We wanted to investigate what potential advantages pECLS may have over current non-pulsatile systems (NPS). Our research was focused on pump’s functional interaction with left ventricle and coronary circulation.Methods: Extensive hemodynamic measurements were performed during asynchronous synchronous in 10 calves. The two extremes regarding LV afterload, namely systolic arrival (SA) diastolic (DA) of pump pulse studied. Results: SA associated increased oxygen consumption (+57%) decreased perfusion(43%). DA ventricular output (DA: 4.5 2.4 l/min vs SA: 3.5 2.2 l/min), LVejection fraction (+10%), efficiency (+17%). Mean aortic pressure mean flow only marginally affected by incidence. Systolic impairment more pronounced higher bypass flows. These results indicate that myocardial working conditions can be optimized phasing ejection into cardiac diastole. Conclusion: conclude pECLS, improved avoidance impairment. Synchronously counterpulsating could a economic versatile alternative NPS or combined intra-aortic balloon pumping. benefits synchronously alternatives remain investigated. # 2005 Elsevier B.V. All rights reserved.