Pharmacokinetics of the bipyridines amrinone and milrinone.

摘要: The pharmacokinetics of milrinone were studied in sequential ascending doses New York Heart Association Class III and IV patients receiving oral intravenous medication. parameters determined after parenteral administration estimated by fitting the plasma concentration data to an open two-compartment body model. After medication, regression-independent determined. either or milrinone, levels dose dependent drug had apparent first-order terminal elimination half-life approximately 2 hr. volume distribution was 400 500 ml/kg, total clearance 130 ml/kg/hr. These values obtained compared with those for volunteers, as well noted other inotropic bipyridine, amrinone. Milrinone's from blood stream slower that normal healthy subjects faster than amrinone's congestive heart failure. pharmacokinetic these unchanged 30 days continuous