Dynamic Observation of Dopamine Autoreceptor Effects in Rat Striatal Slices
作者： Robert T. Kennedy , Sara R. Jones , R. Mark Wightman
DOI: 10.1111/J.1471-4159.1992.TB09391.X
关键词: Quinpirole 、 Endocrinology 、 Pulse (signal processing) 、 Internal medicine 、 Picrotoxin 、 Striatum 、 Chemistry 、 Dopamine 、 Sulpiride 、 Dopamine receptor 、 Autoreceptor
摘要: Fast-scan cyclic voltammetry has been used to measure dopamine (DA) synaptic overflow in slices of rat caudate nucleus induced by electrical stimulation with one-, two-, and 50-pulse, 10-Hz trains. Synaptic this preparation is shown be the result competing effects release cellular uptake. Release caused all pulses was attenuated D2 agonist quinpirole (1 microM). The rapid time response measurements (100 ms) allows autoinhibition endogenous, released DA resolved real time. concentration during second pulse a train 58% that first pulse, an effect partially blocked addition 2 microM sulpiride, antagonist, perfusion buffer. stimulus unaffected suggesting autoreceptors are not normally occupied preparation. third 14% also could enhanced sulpiride. duration inhibition endogenous estimated varying interval between one-pulse stimulations until equal on first; half-time approximately 17 s found. picrotoxin microM) glutamate (10 buffer did affect stimulated DA, although atropine for trains tested.
sci-hub.se 参考文章(27)
AA Grace, BS Bunney, The control of firing pattern in nigral dopamine neurons: burst firing The Journal of Neuroscience. ,vol. 4, pp. 2877- 2890 ,(1984) , 10.1523/JNEUROSCI.04-11-02877.1984
Wayne A. Cass, Nancy R. Zahniser, Inhibition of striatal dopamine release by the selective D-2 dopamine receptor agonist N-0437 is blocked by quinine. Synapse. ,vol. 5, pp. 336- 337 ,(1990) , 10.1002/SYN.890050411
P. Palij, D.R. Bull, M.J. Sheehan, J. Millar, J. Stamford, Z.L. Kruk, P.P.A. Humphrey, Presynaptic regulation of dopamine release in corpus striatum monitored in vitro in real time by fast cyclic voltammetry. Brain Research. ,vol. 509, pp. 172- 174 ,(1990) , 10.1016/0006-8993(90)90329-A
Leslie J. May, R. Mark Wightman, Heterogeneity of stimulated dopamine overflow within rat striatum as observed with in vivo voltammetry Brain Research. ,vol. 487, pp. 311- 320 ,(1989) , 10.1016/0006-8993(89)90835-4
K. Starke, W. Reimann, A. Zumstein, G. Hertting, Effect of dopamine receptor agonists and antagonists on release of dopamine in the rabbit caudate nucleus in vitro. Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 305, pp. 27- 36 ,(1978) , 10.1007/BF00497003
Leslie J. May, Werner G. Kuhr, R. Mark Wightman, Differentiation of dopamine overflow and uptake processes in the extracellular fluid of the rat caudate nucleus with fast-scan in vivo voltammetry. Journal of Neurochemistry. ,vol. 51, pp. 1060- 1069 ,(1988) , 10.1111/J.1471-4159.1988.TB03069.X
R.M. Wightman, C. Amatorh, R.C. Engstrom, P.D. Hale, E.W. Kristensen, W.G. Kuhr, L.J. May, Real-time characterization of dopamine overflow and uptake in the rat striatum. Neuroscience. ,vol. 25, pp. 513- 523 ,(1988) , 10.1016/0306-4522(88)90255-2
Werner G. Kuhr, R. Mark Wightman, Real-time measurement of dopamine release in rat brain. Brain Research. ,vol. 381, pp. 168- 171 ,(1986) , 10.1016/0006-8993(86)90707-9
D.R. Bull, P. Palij, M.J. Sheehan, J. Millar, J.A. Stamford, Z.L. Kruk, P.P.A. Humphrey, Application of fast cyclic voltammetry to measurement of electrically evoked dopamine overflow from brain slices in vitro Journal of Neuroscience Methods. ,vol. 32, pp. 37- 44 ,(1990) , 10.1016/0165-0270(90)90069-R
Julian Millar, Jonathan A. Stamford, Zygmunt L. Kruk, R.Mark Wightman, Electrochemical, pharmacological and electrophysiological evidence of rapid dopamine release and removal in the rat caudate nucleus following electrical stimulation of the median forebrain bundle. European Journal of Pharmacology. ,vol. 109, pp. 341- 348 ,(1985) , 10.1016/0014-2999(85)90394-2