GR43175 does not share the complex pharmacology of the ergots.

摘要: The aim of this study was to compare the effects selective 5-HT1-like receptor agonist, GR43175, with several ergot derivatives in different pharmacological preparations. In rat isolated uterus, ergotamine, dihydroergotamine, ergometrine and methylergometrine (all at concentrations 1 microM) caused marked uterotonic activity whilst GR43175 (10 30 inactive. Similarly, pithed increases diastolic blood pressure (in doses up 1000 micrograms/kg intravenously), intravenously) anaesthetized dogs, both ergotamine (0.3-1000 (1-1000 dose-dependent vasoconstriction carotid artery bed. However, unlike those were accompanied by coronary vasoconstriction. These studies provide further evidence for remarkably vasoconstrictor action GR43175.