Molecular bases of the regulation of bone remodeling by the canonical Wnt signaling pathway.

摘要: Osteoporosis is a common, prevalent, and debilitating condition, particularly in postmenopausal women. Genetics play major role determining peak bone mass fracture risk, but few genes have been demonstrated conclusively to be involved, much less the signaling pathways with which they are affiliated. The identification of mutations gene Lrp5, Wnt coreceptor, as cause for both osteoporotic high-bone disorders implicated canonical pathway regulation. Since other components identified being regulators mass, target affecting homeostasis begun elucidated. This chapter looks at various data indicating that this plays control formation resorption, two key aspects remodeling.