Biology – cancer metabolic phenotype
作者： Miroslava Čuperlović-Culf
关键词: Metabolic phenotype 、 Metabolic pathway 、 Cancer 、 Bioinformatics 、 Malignant transformation 、 Cancer cell 、 Warburg effect 、 Cell biology 、 Carcinogenesis 、 Programmed cell death 、 Biology
摘要: Metabolic changes are one of the crucial hallmarks cancer. An altered metabolism helps cancer cells sustain high proliferative rates and resist cell death signals. A cell’s unstoppable growth its effect on immediate micro-environment may influence later in metabolism. However, an initial transformation must occur prior to significant tumor growth, as this actually provides conditions for tumorigenesis. Currently, several hypotheses being explored effort understand triggers malignant transformation, avenues consequences. This chapter detailed consideration current understanding metabolic phenotype development significance. The specific major oncogenes onco-suppressors cancers is presented. In addition, a description pathways provided. Finally, overview drugs that have been developed many different targets significance included.
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