Laboratory evaluation of the efficacy of lotilaner (Credelio™) against Amblyomma cajennense (sensu lato) infestations of dogs.

摘要: The ixodid tick Amblyomma cajennense (sensu lato) complex, widespread throughout South and Central America, is also present in Mexico, Texas Florida. As a vector of Rickettsia rickettsii, potentially other pathogens, infestations with A. substantial health risk to humans, dogs mammals. Oral administration lotilaner flavored chewable tablets (CredelioTM, Elanco) was previously shown rapidly provide killing activity infesting ticks. This study investigated lotilaner’s efficacy against (s.l.). Twenty purpose-bred Beagles (10 male 10 female) were ranked by Day -5 burdens nymphal (s.l.) randomized either treatment or sham-treated control group. On 0, fed within approximately 30 min prior oral at as close possible 20 mg/kg, the minimum dose rate. For assessments, counts completed 48 h post-treatment after experimental challenge 200 on Days -7, -2, 7, 14, 21 28. Tick group ranged from low 43 95, average infestation remaining above 25% each assessment, thereby meeting requirement for comparison treated Lotilaner 100% post-treatment, nine days post-treatment. Efficacy greater than 99% all subsequent assessments through 30. No treatment-related adverse events observed. results demonstrate that lotilaner, administered orally mg/kg well tolerated, provides rapid reduction existing infestations, sustained residual protection least