Spatial distribution and frequency dependence of arrhythmogenic vagal effects in canine atria.
作者： OLEG F. SHARIFOV , ALEXEY V. ZAITSEV , LEONID V. ROSENSHTRAUKH , ALEXANDR Y. KALIADIN , GALINA G. BELOSHAPKO
DOI: 10.1111/J.1540-8167.2000.TB00176.X
关键词: Anesthesia 、 Vagal stimulation 、 High rate 、 Both atria 、 Frequency dependence 、 Epicardial mapping 、 Internal medicine 、 Cardiology 、 Atrial fibrillation 、 Medicine 、 Right Atrial Appendage 、 Atrial septum
摘要: Arrhythmogenic Vagal Effects in Dog Atria. introduction: Prior studies isolated canine atria demonstrated that acetylcholine-induced reentrant atrial fibrillation (AF) was triggered by multifocal activity the area of normal impulse origin (sinus node-crista terminalis). The aim this study to investigate activation sequence AF induced vagal stimulation (VS) intact dog hearts. Methods and Results: VS (10 50 Hz, 1 msec, 15 V, 5-sec trains) single or multiple premature depolarizations (APDs), and/or 8 10 open chest dogs. Occurrence APDs increased with increasing intensity. Epicardial mapping (254 unipolar electrodes) both showed as a rule emerged from ectopic sites, often right appendage. Activation first cycles only small number (<3 4) unstable circuits were possible at same moment. Moreover, most sustained VS-induced AFs accounted for leading stable circuit activated remainder atria. Conclusion: (1) vagally increases frequency VS. (2) focal are widely distributed over atria. (3) A APD can be sufficient initiation AF. (4) Despite its high rate AF, it may maintained circuit. (5) septum play an important role maintenance
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