Impact of celiac neurolysis on survival in patients with pancreatic cancer.

摘要: Background Pancreatic cancer (PC) often produces pain that is difficult to control. Celiac neurolysis (CN) performed with the goal of improving control and quality life while reducing opioid-related side effects. Objective We aimed evaluate whether CN provides a survival advantage for PC patients. Design Retrospective case-control study. Setting Single tertiary-care referral center. Patients Review prospectively maintained database identified patients unresectable who underwent over 12-year period. Each patient was matched 2 PC. Intervention CN, which included both celiac plexus (CPN) ganglia (CGN). Main Outcome Measurements Median in Kaplan-Meier curves hazard ratios. Results A total 417 were compared 840 controls Baseline characteristics similar except group had greater weight loss requiring opioids. mean 16.6 ± 5.8 mL alcohol administered. For median from time presentation shorter (193 vs 246 days; ratio 1.32; 95% confidence interval, 1.13-1.54). There no difference unilateral or bilateral injection. However, EUS-guided associated longer non-EUS approaches, those received CPN CGN. Limitations center, retrospective. Conclusion Our study suggests an independent predictor shortened prospective needed verify findings determine results other features such as performance status tumor-related characteristics. It also imperative our finding approaches prolongs