Genome-Wide Diet-Gene Interaction Analyses for Risk of Colorectal Cancer
作者： Jane C Figueiredo , Li Hsu , Carolyn M Hutter , Yi Lin , Peter T Campbell
DOI: 10.1371/JOURNAL.PGEN.1004228
关键词: Biology 、 Gene interaction 、 Case-control study 、 Logistic regression 、 Genome-wide association study 、 Genotype 、 Genetics 、 Red meat 、 Oncology 、 Internal medicine 、 Colorectal cancer 、 Meta-analysis 、 Genetics(clinical) 、 Cancer research 、 Ecology, Evolution, Behavior and Systematics 、 Molecular biology
摘要: Dietary factors, including meat, fruits, vegetables and fiber, are associated with colorectal cancer; however, there is limited information as to whether these dietary factors interact genetic variants modify risk of cancer. We tested interactions between approximately 2.7 million for cancer among 9,287 cases 9,117 controls from ten studies. used logistic regression investigate multiplicative gene-diet interactions, well our recently developed Cocktail method that involves a screening step based on marginal associations correlations testing while correcting multiple using weighted hypothesis testing. Per quartile increment in the intake red processed meat were statistically significant increased risks vegetable, fruit fiber lower risks. From case-control analysis, we detected interaction rs4143094 (10p14/near GATA3) consumption (OR = 1.17; p 8.7E-09), which was consistently observed across studies (p heterogeneity 0.78). The individuals rs4143094-TG -TT genotypes 1.20 OR 1.39, respectively) null those GG genotype 1.03). Our results identify novel cancer, highlighting diet may effect disease risk, have important implications prevention.
harvard.edu
core.ac.uk
elsevier.com
doaj.org
uswr.ac.ir参考文章(64)
Bette Caan, T. Dennis Berry, Ashley Coates, Khe Ni Ma, Sandra Edwards, John Potter, Martha L. Slattery, Energy balance and colon cancer--beyond physical activity. Cancer Research. ,vol. 57, pp. 75- 80 ,(1997)
Charles Kooperberg, James Y. Dai, Michael LeBlanc, Ross L Prentice, On two-stage hypothesis testing procedures via asymptotically independent statistics ,(2010)
D. D. Alexander, C. A. Cushing, Red meat and colorectal cancer: a critical summary of prospective epidemiologic studies. Obesity Reviews. ,vol. 12, ,(2011) , 10.1111/J.1467-789X.2010.00785.X
Tomonori Hosoya, Ivan Maillard, James D. Engel, From the cradle to the grave: activities of GATA-3 throughout T-cell development and differentiation Immunological Reviews. ,vol. 238, pp. 110- 125 ,(2010) , 10.1111/J.1600-065X.2010.00954.X
W. James Gauderman, Pingye Zhang, John L. Morrison, Juan Pablo Lewinger, Finding novel genes by testing G × E interactions in a genome-wide association study. Genetic Epidemiology. ,vol. 37, pp. 603- 613 ,(2013) , 10.1002/GEPI.21748
Roopali Bansal Gupta, Noam Harpaz, Steven Itzkowitz, Sabera Hossain, Sierra Matula, Asher Kornbluth, Carol Bodian, Thomas Ullman, Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort study. Gastroenterology. ,vol. 133, pp. 1099- 1105 ,(2007) , 10.1053/J.GASTRO.2007.08.001
R. Zheng, G. A. Blobel, GATA Transcription Factors and Cancer Genes & Cancer. ,vol. 1, pp. 1178- 1188 ,(2010) , 10.1177/1947601911404223
Ian PM Tomlinson, Emily Webb, Luis Carvajal-Carmona, Peter Broderick, Kimberley Howarth, Alan M Pittman, Sarah Spain, Steven Lubbe, Axel Walther, Kate Sullivan, Emma Jaeger, Sarah Fielding, Andrew Rowan, Jayaram Vijayakrishnan, Enric Domingo, Ian Chandler, Zoe Kemp, Mobshra Qureshi, Susan M Farrington, Albert Tenesa, James GD Prendergast, Rebecca A Barnetson, Steven Penegar, Ella Barclay, Wendy Wood, Lynn Martin, Maggie Gorman, Huw Thomas, Julian Peto, D Timothy Bishop, Richard Gray, Eamonn R Maher, Anneke Lucassen, David Kerr, D Gareth R Evans, CORGI Consortium, Clemens Schafmayer, Stephan Buch, Henry Völzke, Jochen Hampe, Stefan Schreiber, Ulrich John, Thibaud Koessler, Paul Pharoah, Tom van Wezel, Hans Morreau, Juul T Wijnen, John L Hopper, Melissa C Southey, Graham G Giles, Gianluca Severi, Sergi Castellví-Bel, Clara Ruiz-Ponte, Angel Carracedo, Antoni Castells, EPICOLON Consortium, Asta Försti, Kari Hemminki, Pavel Vodicka, Alessio Naccarati, Lara Lipton, Judy WC Ho, KK Cheng, Pak C Sham, J Luk, Jose AG Agúndez, Jose M Ladero, Miguel de la Hoya, Trinidad Caldés, Iina Niittymäki, Sari Tuupanen, Auli Karhu, Lauri Aaltonen, Jean-Baptiste Cazier, Harry Campbell, Malcolm G Dunlop, Richard S Houlston, None, A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3 Nature Genetics. ,vol. 40, pp. 623- 630 ,(2008) , 10.1038/NG.111
J. Y. Dai, C. Kooperberg, M. Leblanc, R. L. Prentice, Two-stage testing procedures with independent filtering for genome-wide gene-environment interaction. Biometrika. ,vol. 99, pp. 929- 944 ,(2012) , 10.1093/BIOMET/ASS044
George P. Christophi, Rong Rong, Philip G. Holtzapple, Paul T. Massa, Steve K. Landas, Immune markers and differential signaling networks in ulcerative colitis and Crohn's disease. Inflammatory Bowel Diseases. ,vol. 18, pp. 2342- 2356 ,(2012) , 10.1002/IBD.22957