Immunobiology of parasitic worm extracellular vesicles
作者： Ramon M Eichenberger , Javier Sotillo , Alex Loukas
DOI: 10.1111/IMCB.12171
关键词: Helminths 、 Immune system 、 Cell biology 、 Host (biology) 、 Biology 、 Cell type 、 Exosome 、 Molecular interactions 、 Extracellular vesicle 、 Extracellular vesicles
摘要: Helminth parasites (worms) have evolved a vast array of strategies to manipulate their vertebrate hosts. Extracellular vesicles (EVs) are secreted by all helminth species investigated thus far, and salient roles in parasite-host interactions being revealed. Parasite EVs directly interact with various cell types from hosts, including immune cells, for molecular cargo both regulation promotion inflammation the host been reported. Despite growing body literature on EVs, limited availability genetic manipulation tools research has precluded detailed investigation specific between parasite target cells. Here, we review current state field discuss innovative targeting discovery development new therapeutic strategies, placing particular emphasis anti-helminth vaccines EV small RNAs treating noninfectious inflammatory diseases.
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