Effects of Tumor Microenvironment on Immunity and Consequent Clinical Considerations

摘要: Immune response to cancer is a dynamic process in which uncontrolled growth of cells countered by various protective mechanisms. However, the progression disease can be interpreted as failure antitumor immune response. Recent studies indicate host cooperates with promote their and dissemination through production several factors, cytokines, angiogenic free radicals proteolytic enzymes that are produced stroma coordinated tumor cells. Among microenvironmental factors hypoxia seems play central role these processes promoting mechanisms leading evasion system. Furthermore, recent discovery positive interaction convectional therapeutic modalities, such some chemotherapeutic drugs radiotherapy, will permit new cocktails able kill directly indirectly collaborating