Behçet’s Syndrome According to Classical and Population Genetics
作者： Akira Meguro , Nobuhisa Mizuki , Ahmet Gül , Nobuyoshi Kitaichi , Shigeaki Ohno
DOI: 10.1007/978-88-470-5477-6_4
关键词: Genetic association 、 Disease 、 Immunology 、 Genetic predisposition 、 Genetic variation 、 Allele 、 Etiology 、 Genome-wide association study 、 Human leukocyte antigen 、 Medicine
摘要: Although the etiology of Behcet’s disease (BD) remains uncertain, genetic and environmental factors likely both play an important role in BD development. is strongly associated with human leukocyte antigen (HLA) class I allele, HLA-B*51, many different ethnic groups. However, presence HLA-B*51-negative patients suggests that other and/or are also development BD. Several variations have been recently identified as susceptibility for BD, especially help genome-wide association studies. Those findings provide new insights into pathophysiology allowing a clearer interpretation molecular level, translation those may lead to more accurate diagnostic tools effective treatment approaches
springer.com
sci-hub.st 参考文章(81)
Shigeaki Ohno, Clinical Observations in Behcet′s Disease Japanese Journal of Ophthalmology. ,vol. 23, pp. 126- 131 ,(1979)
A O'Garra, D F Fiorentino, P Vieira, T R Mosmann, A Zlotnik, M Howard, K W Moore, IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. Journal of Immunology. ,vol. 146, pp. 3444- 3451 ,(1991)
J. Kera, N. Mizuki, M. Ota, Y. Katsuyama, P. Pivetti-Pezzi, S. Ohno, H. Inoko, Significant associations of HLA-B*5101 and B*5108, and lack of association of class II alleles with Behcet's disease in Italian patients Tissue Antigens. ,vol. 54, pp. 565- 571 ,(1999) , 10.1034/J.1399-0039.1999.540605.X
Anubhav N. Mathur, Hua-Chen Chang, Dimitrios G. Zisoulis, Gretta L. Stritesky, Qing Yu, John T. O’Malley, Reuben Kapur, David E. Levy, Geoffrey S. Kansas, Mark H. Kaplan, Stat3 and Stat4 Direct Development of IL-17-Secreting Th Cells Journal of Immunology. ,vol. 178, pp. 4901- 4907 ,(2007) , 10.4049/JIMMUNOL.178.8.4901
N Mizuki, S Ohno, H Inoko, K Tsuiji, H Tanaka, J Kera, Human leukocyte antigen serologic and DNA typing of Behçet's disease and its primary association with B51. Investigative Ophthalmology & Visual Science. ,vol. 33, pp. 3332- 3340 ,(1992)
Y.H. Lee, G.G. Song, Associations between eNOS polymorphisms and susceptibility to Behcet's disease: a meta-analysis. Journal of The European Academy of Dermatology and Venereology. ,vol. 26, pp. 1266- 1271 ,(2012) , 10.1111/J.1468-3083.2011.04280.X
Felix Mor, Francisco J. Quintana, Irun R. Cohen, Angiogenesis-inflammation cross-talk: vascular endothelial growth factor is secreted by activated T cells and induces Th1 polarization. Journal of Immunology. ,vol. 172, pp. 4618- 4623 ,(2004) , 10.4049/JIMMUNOL.172.7.4618
Ryuta Nishikomori, Takashi Usui, Chang-Yu Wu, Akio Morinobu, John J. O’Shea, Warren Strober, Activated STAT4 Has an Essential Role in Th1 Differentiation and Proliferation That Is Independent of Its Role in the Maintenance of IL-12Rβ2 Chain Expression and Signaling Journal of Immunology. ,vol. 169, pp. 4388- 4398 ,(2002) , 10.4049/JIMMUNOL.169.8.4388
Luigi Boiardi, Piercarlo Sarzi-Puttini, Carlo Salvarani, Ignazio Olivieri, Giovanni Triolo, Renato Malatesta, Renato La Corte, Enrico Farnetti, Davide Filippini, Fabrizio Cantini, Lia Pulsatelli, Davide Nicoli, Giuseppe Paolazzi, Bruno Casali, Qingquan Chen, Angelo Ferrante, Fabrizio Salvi, Vascular endothelial growth factor gene polymorphisms in Behçet's disease. The Journal of Rheumatology. ,vol. 31, pp. 1785- 1789 ,(2004)
Robert J. B. Nibbs, Theodora W. Salcedo, John D. M. Campbell, Xiao-Tao Yao, Yuling Li, Bernardetta Nardelli, Henrik S. Olsen, Tina S. Morris, Amanda E. I. Proudfoot, Vikram P. Patel, Gerard J. Graham, C-C Chemokine Receptor 3 Antagonism by the β-Chemokine Macrophage Inflammatory Protein 4, a Property Strongly Enhanced by an Amino-Terminal Alanine-Methionine Swap The Journal of Immunology. ,vol. 164, pp. 1488- 1497 ,(2000) , 10.4049/JIMMUNOL.164.3.1488