Original Article Association between RAGE gene polymorphisms and the susceptibility of diabetic nephropathy

作者： Qing-Mei Bai , Wei-Wu Shi , Li-Jie Chen , Jun-Dong Jiao , Guo-Tao Jiang

DOI:

关键词: Internal medicine 、 Allele 、 Gene 、 Diabetic nephropathy 、 Psychology 、 Gastroenterology 、 Immunology 、 Allele frequency 、 Genotype

摘要: Objective: The objective of this study was to investigate the association receptor for advanced glyca- tion end products (RAGE) gene polymorphisms and risk diabetic nephropathy (DN). Methods: Genotypes RAGE (rs1800624, rs1800625 rs2070600) were genotyped by MassArray method. Hardy-Weinberg equilibrium (HWE) utilized detect representative cases controls. Genotype allele frequencies obtained direct calculation. Differences genotypes alleles polymor- phisms between case control groups assessed Chi-square test. SPSS 18.0 used carry out all calculations. Results: rs1800624, rs2070600 higher in type I DN group that group, but differences not significantly (P>0.05). In II patients, rs1800624 related occurrence A polymorphism might act as a factor development patients (P=0.032, OR=1.520, 95% CI=1.036-2.229). total (both DM) no significant observed DN. But both C susceptibility (P=0.030, OR=1.515, CI=1.040-2.209; P=0.043, OR=1.405, CI=1.010-1.956). Conclusion: Rs1800624 associated with risk.

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Original Article Association between RAGE gene polymorphisms and the susceptibility of diabetic nephropathy

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Original Article Association between RAGE gene polymorphisms and the susceptibility of diabetic nephropathy

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