Thymic depletion and peripheral activation of class I major histocompatibility complex-restricted T cells by soluble peptide in T-cell receptor transgenic mice.
作者： C. Mamalaki , T. Norton , Y. Tanaka , A. R. Townsend , P. Chandler
关键词: Influenza virus nucleoprotein 、 T lymphocyte 、 Antigen 、 T-cell receptor 、 Virology 、 CD8 、 Biology 、 CD3 、 Cell biology 、 Major histocompatibility complex 、 Immune system
摘要: Abstract Injection of mice transgenic for a class I major histocompatibility complex-restricted T-cell receptor with soluble peptide antigen from influenza virus nucleoprotein results in clonal depletion double-positive immature thymocytes the thymus and activation mature T cells periphery, accompanied by transient up-regulation CD3 CD8 coreceptor molecules.
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