Antiproliferative effects of L-asparaginase in acute myeloid leukemia.
作者： Tingting Chen , Juan Zhang , Hui Zeng , Yue Zhang , Yong Zhang
关键词: Myeloid leukemia 、 Cancer 、 Mitoxantrone 、 Cancer research 、 Cell cycle 、 Cytarabine 、 Cell growth 、 Cell 、 Apoptosis 、 Medicine
摘要: The antitumor enzyme L-asparaginase (L-Asp) has commonly been used for the treatment of acute lymphoblastic leukemia. However, effects L-Asp on myeloid leukemia (AML) and their underlying mechanisms have not fully elucidated. In present study, cell proliferation apoptosis were investigated using AML lines U937, HL-60 KG-1a. combining with mitoxantrone (MIT) cytarabine (Ara-c) also analyzed. combination MIT Ara-C is known as MA therapy, a widely therapeutic regimen elderly patients refractory AML. When applied alone, inhibited induced in each tested. Furthermore, combined use therapy further potentiated inhibition while increasing induction apoptosis. These findings provide evidence potential effect AML, indicate that improved efficacy maybe achieved by Ara-c. This may promising new strategy
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