Three protein kinase structures define a common motif.

作者: Susan Serota Taylor , Elzbieta Radzio-Andzelm

DOI: 10.1016/S0969-2126(00)00036-8

关键词: MAP2K7c-RafCyclin-dependent kinase 2Cyclin-dependent kinase 9Mitogen-activated protein kinase kinaseASK1ChemistryMAP kinase kinase kinaseBiochemistryCyclin-dependent kinase 4

摘要: … Although all three are relatively small protein kinases, with the genes encoding little more than the catalytic core, they represent three very distinct subclasses of the protein kinase …

参考文章(42)
Madhusudan, Elzbieta A. Trafny, Nguyen-Huu Xuong, Joseph A. Adams, Lynn F.Ten Eyck, Susan S. Taylor, Janusz M. Sowadski, cAMP-dependent protein kinase: crystallographic insights into substrate recognition and phosphotransfer. Protein Science. ,vol. 3, pp. 176- 187 ,(1994) , 10.1002/PRO.5560030203
D. Knighton, J. Zheng, L. Ten Eyck, V. Ashford, N. Xuong, S. Taylor, J. Sowadski, Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase Science. ,vol. 253, pp. 407- 414 ,(1991) , 10.1126/SCIENCE.1862342
M. Veron, E. Radzio-Andzelm, I. Tsigelny, L. F. Ten Eyck, S. S. Taylor, A conserved helix motif complements the protein kinase core. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 10618- 10622 ,(1993) , 10.1073/PNAS.90.22.10618
D. Barford, L. N. Johnson, The allosteric transition of glycogen phosphorylase. Nature. ,vol. 340, pp. 609- 616 ,(1989) , 10.1038/340609A0
D. R. Knighton, S. M. Bell, J. Zheng, L. F. Ten Eyck, N. Xuong, S. S. Taylor, J. M. Sowadski, 2.0 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with a peptide inhibitor and detergent. Acta Crystallographica Section D-biological Crystallography. ,vol. 49, pp. 357- 361 ,(1993) , 10.1107/S0907444993000502
J. Zheng, E. A. Trafny, D. R. Knighton, N. Xuong, S. S. Taylor, L. F. Ten Eyck, J. M. Sowadski, 2.2 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor. Acta Crystallographica Section D-biological Crystallography. ,vol. 49, pp. 362- 365 ,(1993) , 10.1107/S0907444993000423
D. Knighton, J. Zheng, L. Ten Eyck, N. Xuong, S. Taylor, J. Sowadski, Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase Science. ,vol. 253, pp. 414- 420 ,(1991) , 10.1126/SCIENCE.1862343
R. Karlsson, J. Zheng, N. Xuong, S. S. Taylor, J. M. Sowadski, Structure of the mammalian catalytic subunit of cAMP-dependent protein kinase and an inhibitor peptide displays an open conformation. Acta Crystallographica Section D-biological Crystallography. ,vol. 49, pp. 381- 388 ,(1993) , 10.1107/S0907444993002306
M J Marcote, D R Knighton, G Basi, J M Sowadski, P Brambilla, G Draetta, S S Taylor, A three-dimensional model of the Cdc2 protein kinase : localization of cyclin- and Suc1-binding regions and phosphorylation sites Molecular and Cellular Biology. ,vol. 13, pp. 5122- 5131 ,(1993) , 10.1128/MCB.13.8.5122