Spontaneous Alternating Copolymer Vesicles of Alkylmaleimides and Vinyl Gluconamide
作者： Stephen G. Fenimore , Ludmila Abezgauz , Dganit Danino , Chia-Chi Ho , Carlos C. Co
DOI: 10.1021/MA802472J
关键词: Alkyl 、 Vesicle 、 Transmission electron microscopy 、 Dynamic light scattering 、 Copolymer 、 Chemistry 、 Bilayer 、 Monomer 、 Vinyl ether 、 Polymer chemistry
摘要: Alternating copolymers of N-n-alkylmaleimides and vinyl gluconamide spontaneously form ultrasmall- medium-sized (10−20 50−300 nm, respectively) vesicles when dissolved in water at room temperature. These materials have molecular weights that are approximately 100 times higher than those previously reported alternating oligomers alkylmaleate ether monomers conclusively demonstrate can vesicles. The size shape the thoroughly characterized by cryogenic transmission electron microscopy (cryo-TEM), dynamic light scattering (DLS), small-angle neutron (SANS). copolymer exhibit alkyl-chain-length-dependent release characteristics bilayer thickness (1.7, 2.0, 2.6 nm for alkyl chains 10, 12, 14 carbons, respectively).
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Norbert Kučerka, Mikhail A. Kiselev, Pavol Balgavý, Determination of bilayer thickness and lipid surface area in unilamellar dimyristoylphosphatidylcholine vesicles from small-angle neutron scattering curves: a comparison of evaluation methods European Biophysics Journal. ,vol. 33, pp. 328- 334 ,(2004) , 10.1007/S00249-003-0349-0
Katharina Landfester, Regina Rothe, Markus Antonietti, Convenient synthesis of fluorinated latexes and core-shell structures by miniemulsion polymerization Macromolecules. ,vol. 35, pp. 1658- 1662 ,(2002) , 10.1021/MA011608A
Theresa M. Reineke, Mark E. Davis, Structural Effects of Carbohydrate-Containing Polycations on Gene Delivery. 1. Carbohydrate Size and Its Distance from Charge Centers Bioconjugate Chemistry. ,vol. 14, pp. 247- 254 ,(2003) , 10.1021/BC025592K
S. Moazam Mortazavi, M. Reza Mohammadabadi, Kianoush Khosravi-Darani, M. Reza Mozafari, Preparation of liposomal gene therapy vectors by a scalable method without using volatile solvents or detergents. Journal of Biotechnology. ,vol. 129, pp. 604- 613 ,(2007) , 10.1016/J.JBIOTEC.2007.02.005
G. Ciapetti, D. Granchi, E. Verri, L. Savarino, D. Cavedagna, A. Pizzoferrato, Application of a combination of neutral red and amido black staining for rapid, reliable cytotoxicity testing of biomaterials Biomaterials. ,vol. 17, pp. 1259- 1264 ,(1996) , 10.1016/S0142-9612(96)80001-9
Laura L. Brasher, Eric W. Kaler, A Small-Angle Neutron Scattering (SANS) Contrast Variation Investigation of Aggregate Composition in Catanionic Surfactant Mixtures Langmuir. ,vol. 12, pp. 6270- 6276 ,(1996) , 10.1021/LA960493E
Marie Pierre Krafft, Laurent Schieldknecht, Pascal Marie, Françoise Giulieri, Marc Schmutz, Nathalie Poulain, Evelyne Nakache, Fluorinated Vesicles Allow Intrabilayer Polymerization of a Hydrophobic Monomer, Yielding Polymerized Microcapsules Langmuir. ,vol. 17, pp. 2872- 2877 ,(2001) , 10.1021/LA001658T
P. Peter Ghoroghchian, Guizhi Li, Dalia H. Levine, Kevin P. Davis, Frank S. Bates, Daniel A. Hammer, Michael J. Therien, Bioresorbable Vesicles Formed through Spontaneous Self-Assembly of Amphiphilic Poly(ethylene oxide)-block-polycaprolactone Macromolecules. ,vol. 39, pp. 1673- 1675 ,(2006) , 10.1021/MA0519009
Anas El-Aneed, An overview of current delivery systems in cancer gene therapy Journal of Controlled Release. ,vol. 94, pp. 1- 14 ,(2004) , 10.1016/J.JCONREL.2003.09.013
Prasun Bandyopadhyay, Madrid Johnson, Fatty alcohols or fatty acids as niosomal hybrid carrier: Effect on vesicle size, encapsulation efficiency and in vitro dye release Colloids and Surfaces B: Biointerfaces. ,vol. 58, pp. 68- 71 ,(2007) , 10.1016/J.COLSURFB.2007.01.014