Identification of breast cancer-related circRNAs by analysis of microarray and RNA-sequencing data: An observational study.
作者： Chun-Hua Zhao , Le Qu , Hui Zhang , Rui Qu
DOI: 10.1097/MD.0000000000018042
关键词: Carcinogenesis 、 Gene 、 Breast cancer 、 Genome 、 KEGG 、 microRNA 、 Computational biology 、 Competing endogenous RNA 、 Medicine 、 Microarray
摘要: Background An increasing number of studies indicate that circular RNAs (circRNAs) participate in tumorigenesis. The aim this study was to elucidate the regulatory mechanisms circRNAs breast cancer based on construction circRNA-related ceRNA network. Methods expression profiles circRNAs, miRNAs, and mRNAs were obtained from Gene Expression Omnibus (GEO) Cancer Genome Atlas (TCGA) databases. A network constructed by Cytoscape. interactions among proteins analyzed using STRING database, hub genes extracted cytoHubba application. functions differentially expressed (DEmRNAs) Kyoto Encyclopedia Genomes (KEGG) Ontology (GO) database. Results In total, 7 (DEcircRNAs), 27 miRNAs (DEmiRNAs), 102 DEmRNAs selected for cancer. We established a protein-protein interaction identified 6 genes. Then, circRNA-miRNA-hub gene module 2 DEcircRNAs, DEmiRNAs, DEmRNAs. GO KEGG pathway analyses indicated possible association with onset progression. Conclusions circRNA hsa_circ_0000519 is likely critical pathogenesis may serve as future therapeutic biomarker.
sci-hub.se 参考文章(45)
Weidong Li, Xuejun Jin, Qianbing Zhang, Gong Zhang, Xubin Deng, Lei Ma, None, Decreased expression of miR-204 is associated with poor prognosis in patients with breast cancer. International Journal of Clinical and Experimental Pathology. ,vol. 7, pp. 3287- 3292 ,(2014)
Shibin Qu, Xisheng Yang, Xiaolei Li, Jianlin Wang, Yuan Gao, Runze Shang, Wei Sun, Kefeng Dou, Haimin Li, Circular RNA: A new star of noncoding RNAs Cancer Letters. ,vol. 365, pp. 141- 148 ,(2015) , 10.1016/J.CANLET.2015.06.003
Agnieszka Rybak-Wolf, Christin Stottmeister, Petar Glažar, Marvin Jens, Natalia Pino, Sebastian Giusti, Mor Hanan, Mikaela Behm, Osnat Bartok, Reut Ashwal-Fluss, Margareta Herzog, Luisa Schreyer, Panagiotis Papavasileiou, Andranik Ivanov, Marie Öhman, Damian Refojo, Sebastian Kadener, Nikolaus Rajewsky, Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed Molecular Cell. ,vol. 58, pp. 870- 885 ,(2015) , 10.1016/J.MOLCEL.2015.03.027
Kelly L. Mueller, Katelyn Powell, Julie M. Madden, Scott T Eblen, Julie L Boerner, EGFR Tyrosine 845 Phosphorylation-Dependent Proliferation and Transformation of Breast Cancer Cells Require Activation of p38 MAPK Translational Oncology. ,vol. 5, pp. 327- 334 ,(2012) , 10.1593/TLO.12163
Guangchuang Yu, Li-Gen Wang, Yanyan Han, Qing-Yu He, clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters Omics A Journal of Integrative Biology. ,vol. 16, pp. 284- 287 ,(2012) , 10.1089/OMI.2011.0118
Leonardo Salmena, Laura Poliseno, Yvonne Tay, Lev Kats, Pier Paolo Pandolfi, A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language? Cell. ,vol. 146, pp. 353- 358 ,(2011) , 10.1016/J.CELL.2011.07.014
Xia Wang, Jun-Jie Yue, Xian-Wen Ren, Yue-Lan Wang, Ming-Feng Tan, Bei-Ping Li, Long Liang, Modularity analysis based on predicted protein-protein interactions provides new insights into pathogenicity and cellular process of Escherichia coli O157:H7. Theoretical Biology and Medical Modelling. ,vol. 8, pp. 47- 47 ,(2011) , 10.1186/1742-4682-8-47
QIFENG LUO, CHUANKUI WEI, XIAOYU LI, JIA LI, LEI CHEN, YIXIANG HUANG, HONGMING SONG, DENGFENG LI, LIN FANG, MicroRNA-195-5p is a potential diagnostic and therapeutic target for breast cancer. Oncology Reports. ,vol. 31, pp. 1096- 1102 ,(2014) , 10.3892/OR.2014.2971
Balazs Györffy, Andras Lanczky, Aron C Eklund, Carsten Denkert, Jan Budczies, Qiyuan Li, Zoltan Szallasi, None, An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients. Breast Cancer Research and Treatment. ,vol. 123, pp. 725- 731 ,(2010) , 10.1007/S10549-009-0674-9
Bastian Fromm, Tyler Billipp, Liam E. Peck, Morten Johansen, James E. Tarver, Benjamin L. King, James M. Newcomb, Lorenzo F. Sempere, Kjersti Flatmark, Eivind Hovig, Kevin J. Peterson, A Uniform System for the Annotation of Vertebrate microRNA Genes and the Evolution of the Human microRNAome Annual Review of Genetics. ,vol. 49, pp. 213- 242 ,(2015) , 10.1146/ANNUREV-GENET-120213-092023