Recent synthetic scenario on imidazo[1,2- a ]pyridines chemical intermediate

作者: Selvaraj Mohana Roopan , Shashikant Malagoud Patil , Jeyakannu Palaniraja

DOI: 10.1007/S11164-015-2216-X

关键词: Ring (chemistry)Reactivity (chemistry)PyridineImidazoleChemistryDrug moleculeCombinatorial chemistry

摘要: Of the biologically important benzene fused heterocycles, most are those containing a ring-junction nitrogen. The majority of ring junction systems do not occur naturally, but they have been from theoretical viewpoint, for preparation potentially active analogues. imidazo[1,2-a] pyridines an class nitrogen heterocyclic compounds. They huge applications in medicinal chemistry and drug molecule production. Thus, initial discussion focuses on synthetic strategies pyridines, later we disclose reactivity imidazo[1,2-a]pyridines. This review is intended to summarize discuss recent developments synthesis imidazo[1,2-a]pyridines, mainly contributions after 2007.

参考文章(97)
K. Undheim, 4.29 – Five-membered Rings (One Oxygen or Sulfur and At Least One Nitrogen Atom) Fused with Six-membered Rings (At Least One Nitrogen Atom) Reference Module in Chemistry, Molecular Sciences and Chemical Engineering#R##N#Comprehensive Heterocyclic Chemistry. ,vol. 4, pp. 613- 748 ,(1984) , 10.1016/B978-008096519-2.00097-7
Wenlei Ge, Xun Zhu, Yunyang Wei, Aerobic Multicomponent Tandem Synthesis of 3‐Sulfenylimidazo[1,2‐a]pyridines from Ketones, 2‐Aminopyridines, and Disulfides European Journal of Organic Chemistry. ,vol. 2013, pp. 6015- 6020 ,(2013) , 10.1002/EJOC.201300905
F. Couty, G. Evano, Bicyclic 5-6 Systems with One Bridgehead (Ring Junction) Nitrogen Atom: One Extra Heteroatom 1:0 Reference Module in Chemistry, Molecular Sciences and Chemical Engineering#R##N#Comprehensive Heterocyclic Chemistry III. ,vol. 11, pp. 409- 499 ,(2008) , 10.1016/B978-008044992-0.01010-5
Jamal Koubachi, Saïd El Kazzouli, Mosto Bousmina, Gérald Guillaumet, Functionalization of Imidazo[1,2‐a]pyridines by Means of Metal‐Catalyzed Cross‐Coupling Reactions European Journal of Organic Chemistry. ,vol. 2014, pp. 5119- 5138 ,(2014) , 10.1002/EJOC.201400065
Lijuan Ma, Xianpei Wang, Wei Yu, Bing Han, TBAI-catalyzed oxidative coupling of aminopyridines with β-keto esters and 1,3-diones—synthesis of imidazo[1,2-a]pyridines Chemical Communications. ,vol. 47, pp. 11333- 11335 ,(2011) , 10.1039/C1CC13568F
Chuan He, Jing Hao, Huan Xu, Yiping Mo, Huiying Liu, Juanjuan Han, Aiwen Lei, None, Heteroaromatic imidazo[1,2-a]pyridines synthesis from C–H/N–H oxidative cross-coupling/cyclization Chemical Communications. ,vol. 48, pp. 11073- 11075 ,(2012) , 10.1039/C2CC35927H
Ajay N. Jain, Ligand-Based Structural Hypotheses for Virtual Screening Journal of Medicinal Chemistry. ,vol. 47, pp. 947- 961 ,(2004) , 10.1021/JM030520F
Divya K. Nair, Shaikh M. Mobin, Irishi N. N. Namboothiri, Synthesis of Imidazopyridines from the Morita–Baylis–Hillman Acetates of Nitroalkenes and Convenient Access to Alpidem and Zolpidem Organic Letters. ,vol. 14, pp. 4580- 4583 ,(2012) , 10.1021/OL3020418