Synthesis and properties of carbohydrate–phosphate backbone-modified oligonucleotide analogues and nucleic acid mimetics
作者： Tatyana V Abramova , Vladimir N Silnikov
DOI: 10.1070/RC2011V080N05ABEH004188
关键词: Nucleic acid analogue 、 Morpholino 、 Peptide 、 Chemistry 、 Phosphate 、 Nucleic acid 、 Stereochemistry 、 Phosphonate 、 Nucleoside 、 Oligonucleotide 、 General chemistry
摘要: Advances in the synthesis of oligo(deoxy)ribonu- cleotide analogues and nucleic acid mimetics made last decade are summarized. Attention is focused on new methods for derivatives with a modified ribose-phosphate backbone (phosphorothioate, borano- phosphate, nucleoside phosphonate derivatives) devoid phosphate group. Among mimetics, conformationally restricted peptide acids, including those bearing negative or positive charge, morpholino oligomers considered. Advan- tages drawbacks main types as regards complexity possibility their application antisense agents reagents hybrid- ization analysis compared. The bibliography includes 282 references references..
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