Task-dependent recruitment of intrinsic brain networks reflects normative variance in cognition.

摘要: Background Functional neuroimaging has great potential to inform clinical decisions, whether by identifying neural biomarkers of illness progression and severity, predicting therapeutic response, or selecting suitable patients for surgical interventions. Yet a persisting barrier functional neuroimaging's translation is our incomplete understanding how normative variance in cognition, personality, behavior shape the brain's structural organization. We propose that modeling individual differences these brain–behavior relationships crucial improving accuracy neurologic psychiatric disorders. Methods We addressed this goal initiating Cognitive Connectome Project, which bridges neuropsychology pairing nine cognitive domains typically assessed clinically validated neuropsychological measures with those tapped canonical tasks (motor, visuospatial perception, attention, language, memory, affective processing, decision making, working executive function). To date, we have recruited diverse sample 53 participants (mean [SD], age = 32 [9.7] years, 31 females). Results As proof concept, first demonstrate task battery can replicate previous findings performance recruits intrinsic brain networks identified during wakeful rest. then expand upon showing extent are reflects ability. Specifically, on Judgment Line Orientation (a measure perception) administered outside MRI scanner predicts magnitude task-induced activity dorsal visual network when performing direct replication within scanner. Other (such as default mode right frontoparietal) showed changes were unrelated performance, suggesting not be involved perception. Conclusion These establish methodological framework may mutually one another, thus enhancing into making.