SDF-1α expression during wound healing in the aged is HIF dependent

作者: Shang A. Loh , Edward I. Chang , Michael G. Galvez , Hariharan Thangarajah , Samyra El-ftesi

DOI: 10.1097/PRS.0B013E318191BDF4

关键词: ExtramuralHypoxia-Inducible Factor 1Stromal cellCytokineInterleukin-1betaNeovascularizationMedicineImmunologyWound healing

摘要: Background:Age-related impairments in wound healing are associated with decreased neovascularization, a process that is regulated by hypoxia-responsive cytokines, including stromal cell–derived factor (SDF)-1α. Interleukin-1β an important inflammatory cytokine involved and bel

参考文章(38)
Hynda K. Kleinman, Mari E. Swift, Luisa A. DiPietro, Impaired wound repair and delayed angiogenesis in aged mice. Laboratory Investigation. ,vol. 79, pp. 1479- 1487 ,(1999)
Regan Mc, Kirk Sj, Hurson M, Lindblad Wj, Barbul A, Holt Dr, Effect of age on wound healing in healthy human beings. Surgery. ,vol. 112, pp. 293- 298 ,(1992)
Thomas Hellwig-Bürgel, Karen Rutkowski, Eric Metzen, Joachim Fandrey, Wolfgang Jelkmann, Interleukin-1β and Tumor Necrosis Factor- Stimulate DNA Binding of Hypoxia-Inducible Factor-1 Blood. ,vol. 94, pp. 1561- 1567 ,(1999) , 10.1182/BLOOD.V94.5.1561.417A06_1561_1567
Liancun Wu, Yu-Ping Xia, Sanford I. Roth, Elliott Gruskin, Thomas A. Mustoe, Transforming Growth Factor-β1 Fails to Stimulate Wound Healing and Impairs Its Signal Transduction in an Aged Ischemic Ulcer Model : Importance of Oxygen and Age American Journal of Pathology. ,vol. 154, pp. 301- 309 ,(1999) , 10.1016/S0002-9440(10)65276-5
CA Dinarello, Interleukin-1 and interleukin-1 antagonism. Blood. ,vol. 77, pp. 1627- 1652 ,(1991) , 10.1182/BLOOD.V77.8.1627.1627
Zerina Lokmic, Ian A. Darby, Erik W. Thompson, Geraldine M. Mitchell, Time course analysis of hypoxia, granulation tissue and blood vessel growth, and remodeling in healing rat cutaneous incisional primary intention wounds. Wound Repair and Regeneration. ,vol. 14, pp. 277- 288 ,(2006) , 10.1111/J.1743-6109.2006.00122.X
Daniel J Ceradini, Anita R Kulkarni, Matthew J Callaghan, Oren M Tepper, Nicholas Bastidas, Mark E Kleinman, Jennifer M Capla, Robert D Galiano, Jamie P Levine, Geoffrey C Gurtner, Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1 Nature Medicine. ,vol. 10, pp. 858- 864 ,(2004) , 10.1038/NM1075
B PRZYBYLA, C GURLEY, J HARVEY, E BEARDEN, P KORTEBEIN, W EVANS, D SULLIVAN, C PETERSON, R DENNIS, Aging alters macrophage properties in human skeletal muscle both at rest and in response to acute resistance exercise Experimental Gerontology. ,vol. 41, pp. 320- 327 ,(2006) , 10.1016/J.EXGER.2005.12.007
Stephen M. Bauer, Lee J. Goldstein, Richard J. Bauer, Haiying Chen, Mary Putt, Omaida C. Velazquez, The bone marrow-derived endothelial progenitor cell response is impaired in delayed wound healing from ischemia. Journal of Vascular Surgery. ,vol. 43, pp. 134- 141 ,(2006) , 10.1016/J.JVS.2005.08.038