The Hordaland Homocysteine Study: A Community-Based Study of Homocysteine, Its Determinants, and Associations with Disease

摘要: The Hordaland Homocysteine Study (HHS) is a population-based study of more than 18,000 men and women in the county Western Norway. first investigation (HHS-I) took place 1992-93, when subjects were aged 40-67 y. In 1997-99, follow-up (HHS-II) 7,053 was carried out. this large population, plasma levels total homocysteine (tHcy) are associated with several physiologic lifestyle factors common diseases. Increasing age, male sex, smoking, coffee consumption, high blood pressure, unfavorable lipid profile, creatinine, MTHFR 677C > T polymorphism among increased tHcy levels; physical activity, moderate alcohol good folate or vitamin B-12 status lower levels. Subjects raised have risk cardiovascular morbidity, noncardiovascular mortality, likely to suffer from depression cognitive deficit (elderly). Among women, decreased bone mineral density osteoporosis. Women also an having suffered pregnancy complications adverse outcome. Significant associations between clinical outcomes usually observed for 15 micromol/L, but most conditions, there continuous concentration-response relation no apparent threshold concentration. Overall, findings HHS indicate that level multiple whereas low better mental health.