Jejunal T Cell Inflammation in Human Obesity Correlates with Decreased Enterocyte Insulin Signaling
作者： Milena Monteiro-Sepulveda , Sothea Touch , Carla Mendes-Sá , Sébastien André , Christine Poitou
DOI: 10.1016/J.CMET.2015.05.020
关键词: Insulin resistance 、 Internal medicine 、 Cytokine 、 Insulin receptor 、 Immunology 、 Lipid metabolism 、 Lamina propria 、 Biology 、 Endocrinology 、 Enterocyte 、 Inflammation 、 Insulin
摘要: In obesity, insulin resistance is linked to inflammation in several tissues. Although the gut a very large lymphoid tissue, absorptive small intestine, jejunum, where regulates lipid and sugar absorption unknown. We analyzed jejunal samples of 185 obese subjects stratified three metabolic groups: without comorbidity, suffering from obesity-related diabetic, versus 33 lean controls. Obesity increased both mucosa surface due lower cell apoptosis innate adaptive immune populations. The preferential CD8αβ T cell location epithelium over lamina propria appears hallmark obesity. Cytokine secretion by T cells obese, but not lean, blunted signaling enterocytes relevant apical GLUT2 mislocation. Statistical links between densities BMI, NAFLD, or metabolism suggest tissue crosstalk. triggers T-cell-mediated enterocyte jejunum with potential broader systemic implications.
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