Effects of temperature and histopathologic preparation on the size and morphology of atherosclerotic carotid arteries as imaged by MRI.
作者： S�ren Dalager-Pedersen , Erling Falk , Steffen Ringgaard , Ingrid B. Kristensen , Erik M. Pedersen
DOI: 10.1002/(SICI)1522-2586(199911)10:5<876::AID-JMRI37>3.0.CO;2-T
关键词: Morphology (linguistics) 、 Ex vivo 、 Chemistry 、 Pathology 、 Bone decalcification 、 Carotid arteries 、 Histopathology 、 Magnetic resonance imaging 、 Nuclear medicine 、 Fibrous plaque 、 Pulse (signal processing)
摘要: Using magnetic resonance imaging the effects of temperature, formalin fixation, and decalcification on size morphology atherosclerotic arteries were evaluated. Ten ex vivo carotid scanned fresh at body room temperature formalin-fixed decalcified temperature. Different spin-echo pulse sequences used absolute T2 values calculated. During processing for histopathology, contrast between arterial layers increased. From to there significant increases in (4%-7%), media (60--> 68 msec), fibrous plaque component (95--> 110 msec). Formalin fixation caused (2%-3%) (68--> 74 Decalcification shrinkage (2%-5%) decrease (74--> 53 msec) (118--> 76 Thus preparation have profound contrast, size, arteries. Ex experiments should be performed specimens J. Magn. Reson. Imaging 1999;10:876-885.
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