Screening of edible Japanese plants for nitric oxide generation inhibitory activities in RAW 264.7 cells

摘要: A total of 48 (60 test samples) species plants commonly eaten in Japan were randomly collected and their methanol extracts tested for vitro nitric oxide (NO) generation inhibitory activities a murine macrophage cell line, RAW 264.7, stimulated with both lipopolysaccharide (LPS, 100 ng/ml) interferon-γ (IFN-γ, U/ml). Seventeen (28.3%) the strongly inhibited NO at concentration 200 μg/ml by 70% or more significant viability (>50%). The from avocado, taro, red turnip, sereves, komatsuna, basil, mitsuba Chinese mustard markedly iNOS activity. These results suggest that wide variety edible contain secondary metabolites carrying cancer preventive activity through reduction excess amounts NO.