Clopidogrel and 1-year freedom from amputation after endovascular lower extremity revascularization in the Medicare population.

作者: Mark L. Janzen , Viktor Y. Dombrovskiy , Edgar Luis Galiñanes , Todd R. Vogel

DOI: 10.1177/1538574414561233

关键词: In patientClopidogrelMedicare populationAmputationLower extremity revascularizationSurgeryMedicineClaudicationOverall survivalCurrent Procedural Terminology

摘要: Objective: To evaluate freedom from amputation in patients identified utilizing clopidogrel following their lower extremity endovascular revascularization (LER). Methods: Patients, 65 years of age and older, undergoing LER were Medicare Provider Analysis Review Carrier files International Classification Diseases diagnosis Current Procedural Terminology codes. Postprocedural use was using the National Drug Code directory. Outcomes evaluated. Results: A total 14 353 identified: 5697 (39.7%) with claudication, 1467 (10.2%) rest pain, 7189 (50.1%) ulceration/tissue loss. In all, 5416 (37.7%) after LER. Overall, initiated on had rates at 30 days (10.34% vs 14.09%; P < .0001), 90 (14.05% 18.71%; 1 year (19.68% 24.06%;P .0001). Conclusion: Utilization associated amputation, yet only 38% population as clopidogrel. Patients ulceration tissue loss benefited most significantly greater overall survival.

参考文章(22)
Ruby C. Lo, Jeremy Darling, Rodney P. Bensley, Kristina A. Giles, Suzanne E. Dahlberg, Allen D. Hamdan, Mark Wyers, Marc L. Schermerhorn, Outcomes following infrapopliteal angioplasty for critical limb ischemia. Journal of Vascular Surgery. ,vol. 57, pp. 1455- 1464 ,(2013) , 10.1016/J.JVS.2012.10.109
Thomas M Todoran, Gerard Connors, Brian A Engelson, Piotr S Sobieszczyk, Andrew C Eisenhauer, Scott Kinlay, Femoral artery percutaneous revascularization for patients with critical limb ischemia: outcomes compared to patients with claudication over 2.5 years. Vascular Medicine. ,vol. 17, pp. 138- 144 ,(2012) , 10.1177/1358863X12440141
Matthew T. Allemang, Ravi R. Rajani, Peter R. Nelson, Anil Hingorani, Vikram S. Kashyap, Prescribing Patterns of Antiplatelet Agents Are Highly Variable After Lower Extremity Endovascular Procedures Annals of Vascular Surgery. ,vol. 27, pp. 62- 67 ,(2013) , 10.1016/J.AVSG.2012.05.001
P H Beardon, M M McGilchrist, A D McKendrick, D G McDevitt, T M MacDonald, Primary non-compliance with prescribed medication in primary care. BMJ. ,vol. 307, pp. 846- 848 ,(1993) , 10.1136/BMJ.307.6908.846
Bernard G. Jaar, Brad C. Astor, Jeffrey S. Berns, Neil R. Powe, Predictors of amputation and survival following lower extremity revascularization in hemodialysis patients Kidney International. ,vol. 65, pp. 613- 620 ,(2004) , 10.1111/J.1523-1755.2004.00420.X
R.James Valentine, Paul A. Grayburn, Eric J. Eichhorn, Stuart I. Myers, G.Patrick Clagett, Coronary artery disease is highly prevalent among patients with premature peripheral vascular disease Journal of Vascular Surgery. ,vol. 19, pp. 668- 674 ,(1994) , 10.1016/S0741-5214(94)70040-0
Alan T. Hirsch, Ziv J. Haskal, Norman R. Hertzer, Curtis W. Bakal, Mark A. Creager, Jonathan L. Halperin, Loren F. Hiratzka, William R.C. Murphy, Jeffrey W. Olin, Jules B. Puschett, Kenneth A. Rosenfield, David Sacks, James C. Stanley, Lloyd M. Taylor, Christopher J. White, John White, Rodney A. White, Elliott M. Antman, Sidney C. Smith, Cynthia D. Adams, Jeffrey L. Anderson, David P. Faxon, Valentin Fuster, Raymond J. Gibbons, Jonathan L. Halperin, Loren F. Hiratzka, Sharon A. Hunt, Alice K. Jacobs, Rick Nishimura, Joseph P. Ornato, Richard L. Page, Barbara Riegel, ACC/AHA Guidelines for the Management of Patients with Peripheral Arterial Disease (Lower Extremity, Renal, Mesenteric, and Abdominal Aortic) Journal of Vascular and Interventional Radiology. ,vol. 17, pp. 1383- 1398 ,(2006) , 10.1097/01.RVI.0000240426.53079.46