On the Relative Impact of Intraluminal Thrombus Heterogeneity on Abdominal Aortic Aneurysm Mechanics

摘要: Intraluminal thrombus (ILT) is present in the majority of abdominal aortic aneurysms (AAA) a size warranting consideration for surgical or endovascular intervention. The rupture risk AAAs thought to be related balance vessel wall strength and mechanical stress caused by systemic blood pressure. Previous finite element analyses have shown that ILT can reduce homogenize aneurysm stress. These works largely considered homogeneous character idealized stiffness distribution through thickness. In this work, we use MRI delineate heterogeneous composition 7 perform patient-specific analysis under multiple conditions layer disparity. We find explicit incorporation heterogeneity unlikely substantially alter major predictions regarding comparison models assuming homogenous thrombus, provided maximal same between models. Our results also show assumption, choice from values common literature result significantly larger variations compared effects heterogeneity.