Spatial and Temporal Eye–Hand Coordination Relies on the Parietal Reach Region

摘要: Coordinated eye movements are crucial for precision control of our hands. A commonly believed neural mechanism underlying eye–hand coordination is interaction between the networks controlling each effector, exchanging, and matching information, such as movement target location onset time. Alternatively, may result simply from common inputs to independent hand pathways. Thus far, it remains unknown whether where either these two possible mechanisms exists. candidate former mechanism, interpathway communication, includes posterior parietal cortex (PPC) distinct effector-specific areas reside. If PPC were within network coordination, perturbing would affect both that concurrently planned. In contrast, if arises solely inputs, one effector pathway, e.g., reach region (PRR), not other effector. To test hypotheses, we inactivated part PRR in macaque, located medial bank intraparietal sulcus encompassing area 5V. When moved alone, inactivation shortened but saccade amplitudes, compatible with known reach-selective activity PRR. However, when effectors concurrently, decoupled their reaction times. Therefore, consistent communication hypothesis, propose planning concurrent causes spatial information influence otherwise pathways, temporal coupling requires an intact