QT prolongation and fatal arrhythmias: a review of clinical implications and effects of drugs.

摘要: A long QT interval due to prolonged repolarization may be associated with a polymorphic ventricular tachycardia known as torsades de pointes. During marked prolongation of the action potential (long QT) early after depolarizations occur, which when propagated trigger an arrhythmia. The duration QTc is major determinant risk drug-induced torsades. Congenital syndrome, female gender, hypokalemia and use sympathomimetics increase torsades, potentiate prolonging effects drugs. Antiarrhythmics that block potassium channel prolong for (amiodarone, sotalol, quinidine, procainamide, ibutilide, disopyramide). Additionally, some macrolide fluoroquinolone antibiotics, antipsychotic antidepressant drugs, serotonin agonists triptan class, cisapride, dolasetron others have been reported or cases Drug-induced on possibility inducing fatal arrhythmias become new challenge practitioner, drug development process regulatory agencies.